home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 317.3 KB |
open in: 
MacOS 8.1
|
Win98
|
DOS
view JSON data
|
view as text
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000400| 03 00 5a 0e 00 00 37 32 | 00 00 00 01 52 98 03 00 |..Z...72|....R...|
|00000410| 23 0b 00 00 37 33 00 00 | 00 01 75 a3 03 00 96 0c |#...73..|..u.....|
|00000420| 00 00 37 34 00 00 00 01 | 0b b0 03 00 c7 0b 00 00 |..74....|........|
|00000430| 37 35 00 00 00 01 d2 bb | 03 00 cd 11 00 00 37 36 |75......|......76|
|00000440| 00 00 00 01 9f cd 03 00 | 4d 09 00 00 37 37 00 00 |........|M...77..|
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|00000460| f8 e5 03 00 d0 0a 00 00 | 37 39 00 00 00 01 c8 f0 |........|79......|
|00000470| 03 00 18 0d 00 00 38 30 | 00 00 00 01 e0 fd 03 00 |......80|........|
|00000480| fd 0f 00 00 38 31 00 00 | 00 01 dd 0d 04 00 4b 0a |....81..|......K.|
|00000490| 00 00 38 32 00 00 00 01 | 28 18 04 00 02 0d 00 00 |..82....|(.......|
|000004a0| 38 33 00 00 00 01 2a 25 | 04 00 4e 09 00 00 38 34 |83....*%|..N...84|
|000004b0| 00 00 00 01 78 2e 04 00 | 18 0e 00 00 38 35 00 00 |....x...|....85..|
|000004c0| 00 01 90 3c 04 00 6c 0a | 00 00 38 36 00 00 00 01 |...<..l.|..86....|
|000004d0| fc 46 04 00 8f 0f 00 00 | 38 37 00 00 00 01 8b 56 |.F......|87.....V|
|000004e0| 04 00 4f 0c 00 00 38 38 | 00 00 00 01 da 62 04 00 |..O...88|.....b..|
|000004f0| 76 0a 00 00 38 39 00 00 | 00 01 50 6d 04 00 24 0f |v...89..|..Pm..$.|
|00000500| 00 00 39 30 00 00 00 01 | 74 7c 04 00 8b 0a 00 00 |..90....|t|......|
|00000510| 39 31 00 00 00 01 ff 86 | 04 00 73 0d 00 00 39 32 |91......|..s...92|
|00000520| 00 00 00 01 72 94 04 00 | 26 0e 00 00 39 33 00 00 |....r...|&...93..|
|00000530| 00 01 98 a2 04 00 e4 0a | 00 00 39 34 00 00 00 01 |........|..94....|
|00000540| 7c ad 04 00 71 0d 00 00 | 39 35 00 00 00 01 ed ba ||...q...|95......|
|00000550| 04 00 a1 0b 00 00 39 36 | 00 00 00 01 8e c6 04 00 |......96|........|
|00000560| 4e 0d 00 00 39 37 00 00 | 00 01 dc d3 04 00 b6 0c |N...97..|........|
|00000570| 00 00 39 38 00 00 00 01 | 92 e0 04 00 4c 0a 00 00 |..98....|....L...|
|00000580| 39 39 00 00 00 01 de ea | 04 00 2a 0a 00 00 00 00 |99......|..*.....|
|00000590| 00 00 00 00 08 f5 04 00 | 00 00 00 00 24 55 6e 69 |........|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 35 37 30 30 7d |que_ID{Y|RB05700}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 47 6c 79 62 75 72 69 |..$Title|{Glyburi|
|000005c0| 64 65 20 6f 72 20 49 6e | 73 75 6c 69 6e 20 66 6f |de or In|sulin fo|
|000005d0| 72 20 4d 65 74 61 62 6f | 6c 69 63 20 43 6f 6e 74 |r Metabo|lic Cont|
|000005e0| 72 6f 6c 20 69 6e 20 4e | 6f 6e 2d 49 6e 73 75 6c |rol in N|on-Insul|
|000005f0| 69 6e 2d 44 65 70 65 6e | 64 65 6e 74 20 44 69 61 |in-Depen|dent Dia|
|00000600| 62 65 74 65 73 20 4d 65 | 6c 6c 69 74 75 73 3a 20 |betes Me|llitus: |
|00000610| 20 41 20 52 61 6e 64 6f | 6d 69 7a 65 64 2c 20 44 | A Rando|mized, D|
|00000620| 6f 75 62 6c 65 2d 42 6c | 69 6e 64 20 53 74 75 64 |ouble-Bl|ind Stud|
|00000630| 79 7d 0d 0a 24 41 75 74 | 68 6f 72 7b 0d 0a 4e 61 |y}..$Aut|hor{..Na|
|00000640| 74 68 61 6e 2c 20 44 4d | 0d 0a 52 6f 75 73 73 65 |than, DM|..Rousse|
|00000650| 6c 6c 2c 20 41 0d 0a 47 | 6f 64 69 6e 65 2c 20 4a |ll, A..G|odine, J|
|00000660| 45 7d 0d 0a 24 41 66 66 | 69 6c 69 61 74 69 6f 6e |E}..$Aff|iliation|
|00000670| 7b 4d 61 73 73 61 63 68 | 75 73 65 74 74 73 20 47 |{Massach|usetts G|
|00000680| 65 6e 20 48 6f 73 70 2c | 20 42 6f 73 74 6f 6e 3b |en Hosp,| Boston;|
|00000690| 20 48 61 72 76 61 72 64 | 20 4d 65 64 20 53 63 68 | Harvard| Med Sch|
|000006a0| 6f 6f 6c 2c 20 42 6f 73 | 74 6f 6e 7d 0d 0a 24 53 |ool, Bos|ton}..$S|
|000006b0| 75 62 6a 65 63 74 7b 49 | 6e 73 75 6c 69 6e 20 69 |ubject{I|nsulin i|
|000006c0| 6e 20 64 69 61 62 65 74 | 65 73 20 6e 6f 6e 2d 69 |n diabet|es non-i|
|000006d0| 6e 73 75 6c 69 6e 20 64 | 65 70 65 6e 64 65 6e 74 |nsulin d|ependent|
|000006e0| 3b 0d 0a 47 6c 79 62 75 | 72 69 64 65 20 66 6f 72 |;..Glybu|ride for|
|000006f0| 20 6d 65 74 61 62 6f 6c | 69 63 20 63 6f 6e 74 72 | metabol|ic contr|
|00000700| 6f 6c 20 69 6e 20 6e 6f | 6e 2d 69 6e 73 75 6c 69 |ol in no|n-insuli|
|00000710| 6e 2d 64 65 70 65 6e 64 | 65 6e 74 20 64 69 61 62 |n-depend|ent diab|
|00000720| 65 74 65 73 3b 0d 0a 44 | 69 61 62 65 74 65 73 20 |etes;..D|iabetes |
|00000730| 6d 65 6c 6c 69 74 75 73 | 20 6e 6f 6e 2d 69 6e 73 |mellitus| non-ins|
|00000740| 75 6c 69 6e 2d 64 65 70 | 65 6e 64 65 6e 74 2c 20 |ulin-dep|endent, |
|00000750| 67 6c 79 62 75 72 69 64 | 65 20 6f 72 20 69 6e 73 |glyburid|e or ins|
|00000760| 75 6c 69 6e 20 66 6f 72 | 20 6d 65 74 61 62 6f 6c |ulin for| metabol|
|00000770| 69 63 20 63 6f 6e 74 72 | 6f 6c 20 69 6e 7d 0d 0a |ic contr|ol in}..|
|00000780| 24 4a 6f 75 72 6e 61 6c | 7b 41 6e 6e 20 49 6e 74 |$Journal|{Ann Int|
|00000790| 65 72 6e 20 4d 65 64 7d | 0d 0a 24 56 6f 6c 75 6d |ern Med}|..$Volum|
|000007a0| 65 7b 31 30 38 7d 0d 0a | 24 50 61 67 65 7b 33 33 |e{108}..|$Page{33|
|000007b0| 34 2d 33 34 30 7d 0d 0a | 24 44 61 74 65 7b 4d 61 |4-340}..|$Date{Ma|
|000007c0| 72 63 68 20 31 39 38 38 | 7d 0d 0a 24 59 42 56 6f |rch 1988|}..$YBVo|
|000007d0| 6c 7b 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |l{1989 Y|ear Book|
|000007e0| 20 6f 66 20 44 72 75 67 | 20 54 68 65 72 61 70 79 | of Drug| Therapy|
|000007f0| 7d 0d 0a 24 43 68 61 70 | 74 65 72 7b 37 2d 37 7d |}..$Chap|ter{7-7}|
|00000800| 0d 0a 24 59 42 45 64 69 | 74 6f 72 7b 44 72 73 2e |..$YBEdi|tor{Drs.|
|00000810| 20 48 6f 6c 6c 69 73 74 | 65 72 20 61 6e 64 20 4c | Hollist|er and L|
|00000820| 61 73 61 67 6e 61 7d 0d | 0a 24 54 61 62 6c 65 7b |asagna}.|.$Table{|
|00000830| 54 61 62 6c 65 20 4f 6d | 69 74 74 65 64 7d 0d 0a |Table Om|itted}..|
|00000840| 24 43 6f 6d 6d 65 6e 74 | 61 74 6f 72 7b 4c 2e 45 |$Comment|ator{L.E|
|00000850| 2e 20 48 6f 6c 6c 69 73 | 74 65 72 2c 20 4d 2e 44 |. Hollis|ter, M.D|
|00000860| 2e 7d 0d 0a 0d 0a 43 6f | 70 79 72 69 67 68 74 20 |.}....Co|pyright |
|00000870| 28 63 29 20 59 65 61 72 | 20 42 6f 6f 6b 20 4d 65 |(c) Year| Book Me|
|00000880| 64 69 63 61 6c 20 50 75 | 62 6c 69 73 68 65 72 73 |dical Pu|blishers|
|00000890| 2c 20 49 6e 63 2e 2c 20 | 31 39 38 39 0d 0a 0d 0a |, Inc., |1989....|
|000008a0| 31 39 38 39 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1989 Yea|r Book o|
|000008b0| 66 20 44 72 75 67 20 54 | 68 65 72 61 70 79 20 28 |f Drug T|herapy (|
|000008c0| 52 29 0d 0a 0d 0a 43 68 | 61 70 74 65 72 20 37 2d |R)....Ch|apter 7-|
|000008d0| 2d 45 6e 64 6f 63 72 69 | 6e 65 20 61 6e 64 20 4d |-Endocri|ne and M|
|000008e0| 65 74 61 62 6f 6c 69 63 | 20 44 69 73 6f 72 64 65 |etabolic| Disorde|
|000008f0| 72 73 0d 0a 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |rs....--|--------|
|00000900| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000920| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000940| 2d 2d 2d 2d 2d 2d 0d 0a | 47 6c 79 62 75 72 69 64 |------..|Glyburid|
|00000950| 65 20 6f 72 20 49 6e 73 | 75 6c 69 6e 20 66 6f 72 |e or Ins|ulin for|
|00000960| 20 4d 65 74 61 62 6f 6c | 69 63 20 43 6f 6e 74 72 | Metabol|ic Contr|
|00000970| 6f 6c 20 69 6e 20 4e 6f | 6e 2d 49 6e 73 75 6c 69 |ol in No|n-Insuli|
|00000980| 6e 2d 44 65 70 65 6e 64 | 65 6e 74 20 44 69 61 62 |n-Depend|ent Diab|
|00000990| 65 74 65 73 0d 0a 4d 65 | 6c 6c 69 74 75 73 3a 20 |etes..Me|llitus: |
|000009a0| 20 41 20 52 61 6e 64 6f | 6d 69 7a 65 64 2c 20 44 | A Rando|mized, D|
|000009b0| 6f 75 62 6c 65 2d 42 6c | 69 6e 64 20 53 74 75 64 |ouble-Bl|ind Stud|
|000009c0| 79 0d 0a 0d 0a 4e 61 74 | 68 61 6e 20 44 4d 2c 20 |y....Nat|han DM, |
|000009d0| 52 6f 75 73 73 65 6c 6c | 20 41 2c 20 47 6f 64 69 |Roussell| A, Godi|
|000009e0| 6e 65 20 4a 45 0d 0a 28 | 4d 61 73 73 61 63 68 75 |ne JE..(|Massachu|
|000009f0| 73 65 74 74 73 20 47 65 | 6e 20 48 6f 73 70 2c 20 |setts Ge|n Hosp, |
|00000a00| 42 6f 73 74 6f 6e 3b 20 | 48 61 72 76 61 72 64 20 |Boston; |Harvard |
|00000a10| 4d 65 64 20 53 63 68 6f | 6f 6c 2c 20 42 6f 73 74 |Med Scho|ol, Bost|
|00000a20| 6f 6e 29 0d 0a 41 6e 6e | 20 49 6e 74 65 72 6e 20 |on)..Ann| Intern |
|00000a30| 4d 65 64 20 31 30 38 3a | 33 33 34 2d 33 34 30 2c |Med 108:|334-340,|
|00000a40| 20 4d 61 72 63 68 20 31 | 39 38 38 0d 0a 2d 2d 2d | March 1|988..---|
|00000a50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 0d |--------|-----...|
|00000aa0| 0a 41 62 73 74 72 61 63 | 74 0d 0a 0d 0a 20 20 20 |.Abstrac|t.... |
|00000ab0| 20 20 4d 61 6e 79 20 61 | 75 74 68 6f 72 73 20 71 | Many a|uthors q|
|00000ac0| 75 65 73 74 69 6f 6e 20 | 74 68 65 20 72 65 6c 61 |uestion |the rela|
|00000ad0| 74 69 76 65 20 73 61 66 | 65 74 79 20 61 6e 64 20 |tive saf|ety and |
|00000ae0| 62 65 6e 65 66 69 74 73 | 20 6f 66 20 6f 72 61 6c |benefits| of oral|
|00000af0| 20 61 67 65 6e 74 73 0d | 0a 76 65 72 73 75 73 20 | agents.|.versus |
|00000b00| 69 6e 73 75 6c 69 6e 20 | 66 6f 72 20 6d 65 74 61 |insulin |for meta|
|00000b10| 62 6f 6c 69 63 20 63 6f | 6e 74 72 6f 6c 20 69 6e |bolic co|ntrol in|
|00000b20| 20 6e 6f 6e 2d 69 6e 73 | 75 6c 69 6e 2d 64 65 70 | non-ins|ulin-dep|
|00000b30| 65 6e 64 65 6e 74 20 70 | 61 74 69 65 6e 74 73 20 |endent p|atients |
|00000b40| 77 69 74 68 0d 0a 64 69 | 61 62 65 74 65 73 20 6d |with..di|abetes m|
|00000b50| 65 6c 6c 69 74 75 73 2e | 20 20 41 20 72 61 6e 64 |ellitus.| A rand|
|00000b60| 6f 6d 69 7a 65 64 2c 20 | 64 6f 75 62 6c 65 2d 62 |omized, |double-b|
|00000b70| 6c 69 6e 64 20 73 74 75 | 64 79 20 77 61 73 20 64 |lind stu|dy was d|
|00000b80| 65 73 69 67 6e 65 64 20 | 74 6f 20 63 6f 6d 70 61 |esigned |to compa|
|00000b90| 72 65 0d 0a 69 6e 73 75 | 6c 69 6e 20 76 65 72 73 |re..insu|lin vers|
|00000ba0| 75 73 20 67 6c 79 62 75 | 72 69 64 65 20 69 6e 20 |us glybu|ride in |
|00000bb0| 61 63 68 69 65 76 69 6e | 67 20 6e 6f 72 6d 6f 67 |achievin|g normog|
|00000bc0| 6c 79 63 65 6d 69 61 20 | 69 6e 20 74 68 65 73 65 |lycemia |in these|
|00000bd0| 20 70 61 74 69 65 6e 74 | 73 2e 0d 0a 54 68 69 72 | patient|s...Thir|
|00000be0| 74 79 2d 6f 6e 65 20 70 | 61 74 69 65 6e 74 73 20 |ty-one p|atients |
|00000bf0| 69 6e 20 77 68 6f 6d 20 | 64 69 65 74 20 63 6f 75 |in whom |diet cou|
|00000c00| 6c 64 20 6e 6f 74 20 61 | 63 68 69 65 76 65 20 6e |ld not a|chieve n|
|00000c10| 6f 72 6d 61 6c 20 67 6c | 75 63 6f 73 65 20 63 6f |ormal gl|ucose co|
|00000c20| 6e 74 72 6f 6c 20 77 65 | 72 65 0d 0a 72 61 6e 64 |ntrol we|re..rand|
|00000c30| 6f 6d 69 7a 65 64 20 74 | 6f 20 72 65 63 65 69 76 |omized t|o receiv|
|00000c40| 65 20 65 69 74 68 65 72 | 20 6f 72 61 6c 20 67 6c |e either| oral gl|
|00000c50| 79 62 75 72 69 64 65 20 | 6f 72 20 69 6e 73 75 6c |yburide |or insul|
|00000c60| 69 6e 20 69 6e 6a 65 63 | 74 69 6f 6e 20 61 6e 64 |in injec|tion and|
|00000c70| 20 70 6c 61 63 65 62 6f | 0d 0a 69 6e 6a 65 63 74 | placebo|..inject|
|00000c80| 69 6f 6e 20 6f 72 20 70 | 6c 61 63 65 62 6f 20 74 |ion or p|lacebo t|
|00000c90| 61 62 6c 65 74 20 66 6f | 72 20 74 68 65 20 61 6c |ablet fo|r the al|
|00000ca0| 74 65 72 6e 61 74 65 20 | 64 72 75 67 2e 0d 0a 20 |ternate |drug... |
|00000cb0| 20 20 20 20 47 72 6f 75 | 70 73 20 77 65 72 65 20 | Grou|ps were |
|00000cc0| 73 69 6d 69 6c 61 72 20 | 69 6e 20 69 6d 70 72 6f |similar |in impro|
|00000cd0| 76 65 6d 65 6e 74 20 69 | 6e 20 66 61 73 74 69 6e |vement i|n fastin|
|00000ce0| 67 20 62 6c 6f 6f 64 20 | 67 6c 75 63 6f 73 65 20 |g blood |glucose |
|00000cf0| 6c 65 76 65 6c 73 20 61 | 6e 64 0d 0a 68 65 6d 6f |levels a|nd..hemo|
|00000d00| 67 6c 6f 62 69 6e 20 41 | 31 63 20 63 6f 6e 63 65 |globin A|1c conce|
|00000d10| 6e 74 72 61 74 69 6f 6e | 73 2c 20 66 72 65 71 75 |ntration|s, frequ|
|00000d20| 65 6e 63 79 20 6f 66 20 | 6d 69 6c 64 20 68 79 70 |ency of |mild hyp|
|00000d30| 6f 67 6c 79 63 65 6d 69 | 61 2c 20 61 6e 64 20 77 |oglycemi|a, and w|
|00000d40| 65 69 67 68 74 20 67 61 | 69 6e 2e 0d 0a 49 6e 20 |eight ga|in...In |
|00000d50| 62 6f 74 68 20 67 72 6f | 75 70 73 20 74 72 69 67 |both gro|ups trig|
|00000d60| 6c 79 63 65 72 69 64 65 | 20 61 6e 64 20 63 68 6f |lyceride| and cho|
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|00000e50| 20 20 47 6c 79 62 75 72 | 69 64 65 20 61 6e 64 20 | Glybur|ide and |
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|00000ed0| 6e 73 75 6c 69 6e 20 6d | 61 79 20 6f 66 66 65 72 |nsulin m|ay offer|
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|00000fc0| 79 0d 0a 65 66 66 65 63 | 74 69 76 65 20 69 6e 20 |y..effec|tive in |
|00000fd0| 63 6f 6e 74 72 6f 6c 6c | 69 6e 67 20 70 72 65 73 |controll|ing pres|
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|00000ff0| 2d 64 65 70 65 6e 64 65 | 6e 74 20 64 69 61 62 65 |-depende|nt diabe|
|00001000| 74 69 63 73 2e 20 20 54 | 68 65 20 6f 72 61 6c 0d |tics. T|he oral.|
|00001010| 0a 61 67 65 6e 74 20 68 | 61 73 20 74 68 65 20 61 |.agent h|as the a|
|00001020| 64 76 61 6e 74 61 67 65 | 20 6f 66 20 67 72 65 61 |dvantage| of grea|
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|00001080| 69 6e 73 75 6c 69 6e 20 | 73 75 72 70 61 73 73 20 |insulin |surpass |
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|00002210| 53 65 70 74 65 6d 62 65 | 72 20 31 39 38 37 0d 0a |Septembe|r 1987..|
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|00002c30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002c70| 0d 0a 50 72 6f 6c 6f 6e | 67 65 64 20 57 65 69 67 |..Prolon|ged Weig|
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|00002ca0| 61 74 6d 65 6e 74 20 69 | 6e 20 4f 62 65 73 65 20 |atment i|n Obese |
|00002cb0| 50 61 74 69 65 6e 74 73 | 0d 0a 0d 0a 46 69 6e 65 |Patients|....Fine|
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|00002cd0| 20 4c 61 76 69 65 6c 6c | 65 20 52 2c 20 4b 65 65 | Laviell|e R, Kee|
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|00002d30| 72 61 6e 63 65 29 0d 0a | 44 69 61 62 65 74 65 73 |rance)..|Diabetes|
|00002d40| 20 4d 65 74 61 62 20 28 | 50 61 72 69 73 29 20 31 | Metab (|Paris) 1|
|00002d50| 33 3a 35 39 38 2d 36 30 | 32 2c 20 4e 6f 76 65 6d |3:598-60|2, Novem|
|00002d60| 62 65 72 2d 44 65 63 65 | 6d 62 65 72 20 31 39 0d |ber-Dece|mber 19.|
|00002d70| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|00002d80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002d90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002da0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002db0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002dc0| 2d 0d 0a 0d 0a 41 62 73 | 74 72 61 63 74 0d 0a 0d |-....Abs|tract...|
|00002dd0| 0a 20 20 20 20 20 44 65 | 78 66 65 6e 66 6c 75 72 |. De|xfenflur|
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|00002e10| 69 6e 20 31 37 20 70 61 | 74 69 65 6e 74 73 0d 0a |in 17 pa|tients..|
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|00002ed0| 20 20 54 68 65 73 65 20 | 70 61 74 69 65 6e 74 73 | These |patients|
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|00002ef0| 6f 66 20 64 65 78 66 65 | 6e 66 6c 75 72 61 6d 69 |of dexfe|nflurami|
|00002f00| 6e 65 0d 0a 74 77 69 63 | 65 20 64 61 69 6c 79 20 |ne..twic|e daily |
|00002f10| 66 6f 72 20 36 20 6d 6f | 6e 74 68 73 2e 0d 0a 20 |for 6 mo|nths... |
|00002f20| 20 20 20 20 54 68 65 20 | 66 69 72 73 74 20 67 72 | The |first gr|
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|00002fb0| 20 49 6e 20 74 68 65 0d | 0a 6c 6f 6e 67 2d 74 65 | In the.|.long-te|
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|00003030| 20 63 75 6d 75 6c 61 74 | 69 76 65 20 6c 6f 73 73 | cumulat|ive loss|
|00003040| 20 77 61 73 20 37 20 6b | 67 2e 20 20 53 69 64 65 | was 7 k|g. Side|
|00003050| 20 65 66 66 65 63 74 73 | 0d 0a 77 65 72 65 20 6d | effects|..were m|
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|00003080| 6f 66 20 74 72 65 61 74 | 6d 65 6e 74 2e 0d 0a 20 |of treat|ment... |
|00003090| 20 20 20 20 44 65 78 66 | 65 6e 66 6c 75 72 61 6d | Dexf|enfluram|
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|00004330| 0d 0a 48 79 70 65 72 70 | 72 6f 6c 61 63 74 69 6e |..Hyperp|rolactin|
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|00004390| 64 72 61 77 61 6c 20 69 | 6e 7d 0d 0a 24 4a 6f 75 |drawal i|n}..$Jou|
|000043a0| 72 6e 61 6c 7b 43 6c 69 | 6e 20 45 6e 64 6f 63 72 |rnal{Cli|n Endocr|
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|000043c0| 6c 75 6d 65 7b 32 37 7d | 0d 0a 24 50 61 67 65 7b |lume{27}|..$Page{|
|000043d0| 33 36 33 2d 33 37 31 7d | 0d 0a 24 44 61 74 65 7b |363-371}|..$Date{|
|000043e0| 53 65 70 74 65 6d 62 65 | 72 20 31 39 38 37 7d 0d |Septembe|r 1987}.|
|000043f0| 0a 24 59 42 56 6f 6c 7b | 31 39 38 39 20 59 65 61 |.$YBVol{|1989 Yea|
|00004400| 72 20 42 6f 6f 6b 20 6f | 66 20 44 72 75 67 20 54 |r Book o|f Drug T|
|00004410| 68 65 72 61 70 79 7d 0d | 0a 24 43 68 61 70 74 65 |herapy}.|.$Chapte|
|00004420| 72 7b 37 2d 31 32 7d 0d | 0a 24 59 42 45 64 69 74 |r{7-12}.|.$YBEdit|
|00004430| 6f 72 7b 44 72 73 2e 20 | 48 6f 6c 6c 69 73 74 65 |or{Drs. |Holliste|
|00004440| 72 20 61 6e 64 20 4c 61 | 73 61 67 6e 61 7d 0d 0a |r and La|sagna}..|
|00004450| 24 54 61 62 6c 65 7b 7d | 0d 0a 24 43 6f 6d 6d 65 |$Table{}|..$Comme|
|00004460| 6e 74 61 74 6f 72 7b 4c | 2e 45 2e 20 48 6f 6c 6c |ntator{L|.E. Holl|
|00004470| 69 73 74 65 72 2c 20 4d | 2e 44 2e 7d 0d 0a 0d 0a |ister, M|.D.}....|
|00004480| 43 6f 70 79 72 69 67 68 | 74 20 28 63 29 20 59 65 |Copyrigh|t (c) Ye|
|00004490| 61 72 20 42 6f 6f 6b 20 | 4d 65 64 69 63 61 6c 20 |ar Book |Medical |
|000044a0| 50 75 62 6c 69 73 68 65 | 72 73 2c 20 49 6e 63 2e |Publishe|rs, Inc.|
|000044b0| 2c 20 31 39 38 39 0d 0a | 0d 0a 31 39 38 39 20 59 |, 1989..|..1989 Y|
|000044c0| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 44 72 75 67 |ear Book| of Drug|
|000044d0| 20 54 68 65 72 61 70 79 | 20 28 52 29 0d 0a 0d 0a | Therapy| (R)....|
|000044e0| 43 68 61 70 74 65 72 20 | 37 2d 2d 45 6e 64 6f 63 |Chapter |7--Endoc|
|000044f0| 72 69 6e 65 20 61 6e 64 | 20 4d 65 74 61 62 6f 6c |rine and| Metabol|
|00004500| 69 63 20 44 69 73 6f 72 | 64 65 72 73 0d 0a 0d 0a |ic Disor|ders....|
|00004510| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004520| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004530| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004540| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004550| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004560| 0d 0a 4c 6f 6e 67 2d 74 | 65 72 6d 20 54 72 65 61 |..Long-t|erm Trea|
|00004570| 74 6d 65 6e 74 20 6f 66 | 20 48 79 70 65 72 70 72 |tment of| Hyperpr|
|00004580| 6f 6c 61 63 74 69 6e 61 | 65 6d 69 61 20 57 69 74 |olactina|emia Wit|
|00004590| 68 20 42 72 6f 6d 6f 63 | 72 69 70 74 69 6e 65 3a |h Bromoc|riptine:|
|000045a0| 20 20 45 66 66 65 63 74 | 20 6f 66 20 44 72 75 67 | Effect| of Drug|
|000045b0| 0d 0a 57 69 74 68 64 72 | 61 77 61 6c 0d 0a 0d 0a |..Withdr|awal....|
|000045c0| 57 61 6e 67 20 43 2c 20 | 4c 61 6d 20 4b 53 4c 2c |Wang C, |Lam KSL,|
|000045d0| 20 4d 61 20 4a 54 43 2c | 20 43 68 61 6e 20 54 2c | Ma JTC,| Chan T,|
|000045e0| 20 4c 69 75 20 4d 59 2c | 20 59 65 75 6e 67 20 52 | Liu MY,| Yeung R|
|000045f0| 54 54 0d 0a 28 55 6e 69 | 76 20 6f 66 20 48 6f 6e |TT..(Uni|v of Hon|
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|00004620| 37 3a 33 36 33 2d 33 37 | 31 2c 20 53 65 70 74 65 |7:363-37|1, Septe|
|00004630| 6d 62 65 72 20 31 39 38 | 37 0d 0a 2d 2d 2d 2d 2d |mber 198|7..-----|
|00004640| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004650| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004660| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004670| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004680| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
|00004690| 62 73 74 72 61 63 74 0d | 0a 0d 0a 20 20 20 20 20 |bstract.|... |
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|00004750| 20 6d 61 63 72 6f 61 64 | 65 6e 6f 6d 61 73 2c 20 | macroad|enomas, |
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|00005060| 0a 24 4a 6f 75 72 6e 61 | 6c 7b 4c 61 6e 63 65 74 |.$Journa|l{Lancet|
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|00005080| 50 61 67 65 7b 35 35 32 | 2d 35 35 35 7d 0d 0a 24 |Page{552|-555}..$|
|00005090| 44 61 74 65 7b 53 65 70 | 74 20 35 2c 20 31 39 38 |Date{Sep|t 5, 198|
|000050a0| 37 7d 0d 0a 24 59 42 56 | 6f 6c 7b 31 39 38 39 20 |7}..$YBV|ol{1989 |
|000050b0| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 44 72 75 |Year Boo|k of Dru|
|000050c0| 67 20 54 68 65 72 61 70 | 79 7d 0d 0a 24 43 68 61 |g Therap|y}..$Cha|
|000050d0| 70 74 65 72 7b 37 2d 31 | 33 7d 0d 0a 24 59 42 45 |pter{7-1|3}..$YBE|
|000050e0| 64 69 74 6f 72 7b 44 72 | 73 2e 20 48 6f 6c 6c 69 |ditor{Dr|s. Holli|
|000050f0| 73 74 65 72 20 61 6e 64 | 20 4c 61 73 61 67 6e 61 |ster and| Lasagna|
|00005100| 7d 0d 0a 24 54 61 62 6c | 65 7b 7d 0d 0a 24 43 6f |}..$Tabl|e{}..$Co|
|00005110| 6d 6d 65 6e 74 61 74 6f | 72 7b 4c 2e 45 2e 20 48 |mmentato|r{L.E. H|
|00005120| 6f 6c 6c 69 73 74 65 72 | 2c 20 4d 2e 44 2e 7d 0d |ollister|, M.D.}.|
|00005130| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 63 29 |...Copyr|ight (c)|
|00005140| 20 59 65 61 72 20 42 6f | 6f 6b 20 4d 65 64 69 63 | Year Bo|ok Medic|
|00005150| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00005160| 6e 63 2e 2c 20 31 39 38 | 39 0d 0a 0d 0a 31 39 38 |nc., 198|9....198|
|00005170| 39 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 44 |9 Year B|ook of D|
|00005180| 72 75 67 20 54 68 65 72 | 61 70 79 20 28 52 29 0d |rug Ther|apy (R).|
|00005190| 0a 0d 0a 43 68 61 70 74 | 65 72 20 37 2d 2d 45 6e |...Chapt|er 7--En|
|000051a0| 64 6f 63 72 69 6e 65 20 | 61 6e 64 20 4d 65 74 61 |docrine |and Meta|
|000051b0| 62 6f 6c 69 63 20 44 69 | 73 6f 72 64 65 72 73 0d |bolic Di|sorders.|
|000051c0| 0a 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |...-----|--------|
|000051d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000051e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000051f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005200| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005210| 2d 2d 2d 0d 0a 49 6e 64 | 75 63 74 69 6f 6e 20 6f |---..Ind|uction o|
|00005220| 66 20 50 75 62 65 72 74 | 79 20 62 79 20 50 75 6c |f Pubert|y by Pul|
|00005230| 73 61 74 69 6c 65 20 47 | 6f 6e 61 64 6f 74 72 6f |satile G|onadotro|
|00005240| 70 69 6e 20 52 65 6c 65 | 61 73 69 6e 67 20 48 6f |pin Rele|asing Ho|
|00005250| 72 6d 6f 6e 65 0d 0a 0d | 0a 53 74 61 6e 68 6f 70 |rmone...|.Stanhop|
|00005260| 65 20 52 2c 20 42 72 6f | 6f 6b 20 43 47 44 2c 20 |e R, Bro|ok CGD, |
|00005270| 50 72 69 6e 67 6c 65 20 | 50 4a 2c 20 41 64 61 6d |Pringle |PJ, Adam|
|00005280| 73 20 4a 2c 20 4a 61 63 | 6f 62 73 20 48 53 0d 0a |s J, Jac|obs HS..|
|00005290| 28 54 68 65 20 4d 69 64 | 64 6c 65 73 65 78 20 48 |(The Mid|dlesex H|
|000052a0| 6f 73 70 2c 20 4c 6f 6e | 64 6f 6e 29 0d 0a 4c 61 |osp, Lon|don)..La|
|000052b0| 6e 63 65 74 20 32 3a 35 | 35 32 2d 35 35 35 2c 20 |ncet 2:5|52-555, |
|000052c0| 53 65 70 74 20 35 2c 20 | 31 39 38 37 0d 0a 2d 2d |Sept 5, |1987..--|
|000052d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000052e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000052f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005300| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005310| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 0d 0a |--------|------..|
|00005320| 0d 0a 41 62 73 74 72 61 | 63 74 0d 0a 0d 0a 20 20 |..Abstra|ct.... |
|00005330| 20 20 20 4c 6f 77 2d 64 | 6f 73 65 20 70 75 6c 73 | Low-d|ose puls|
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|00005d00| 6f 72 7b 44 72 73 2e 20 | 48 6f 6c 6c 69 73 74 65 |or{Drs. |Holliste|
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|00005d70| 50 75 62 6c 69 73 68 65 | 72 73 2c 20 49 6e 63 2e |Publishe|rs, Inc.|
|00005d80| 2c 20 31 39 38 39 0d 0a | 0d 0a 31 39 38 39 20 59 |, 1989..|..1989 Y|
|00005d90| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 44 72 75 67 |ear Book| of Drug|
|00005da0| 20 54 68 65 72 61 70 79 | 20 28 52 29 0d 0a 0d 0a | Therapy| (R)....|
|00005db0| 43 68 61 70 74 65 72 20 | 37 2d 2d 45 6e 64 6f 63 |Chapter |7--Endoc|
|00005dc0| 72 69 6e 65 20 61 6e 64 | 20 4d 65 74 61 62 6f 6c |rine and| Metabol|
|00005dd0| 69 63 20 44 69 73 6f 72 | 64 65 72 73 0d 0a 0d 0a |ic Disor|ders....|
|00005de0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005df0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005e00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005e10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005e20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005e30| 0d 0a 41 6e 64 72 6f 67 | 65 6e 20 54 68 65 72 61 |..Androg|en Thera|
|00005e40| 70 79 20 6f 66 20 48 79 | 70 6f 67 6f 6e 61 64 61 |py of Hy|pogonada|
|00005e50| 6c 20 4d 65 6e 20 57 69 | 74 68 20 54 72 61 6e 73 |l Men Wi|th Trans|
|00005e60| 73 63 72 6f 74 61 6c 20 | 54 65 73 74 6f 73 74 65 |scrotal |Testoste|
|00005e70| 72 6f 6e 65 20 53 79 73 | 74 65 6d 73 0d 0a 0d 0a |rone Sys|tems....|
|00005e80| 4b 6f 72 65 6e 6d 61 6e | 20 47 2c 20 56 69 6f 73 |Korenman| G, Vios|
|00005e90| 63 61 20 53 2c 20 47 61 | 72 7a 61 20 44 2c 20 47 |ca S, Ga|rza D, G|
|00005ea0| 75 72 61 6c 6e 69 6b 20 | 4d 2c 20 50 6c 61 63 65 |uralnik |M, Place|
|00005eb0| 20 56 2c 20 43 61 6d 70 | 62 65 6c 6c 20 50 2c 20 | V, Camp|bell P, |
|00005ec0| 44 61 76 69 73 20 53 53 | 0d 0a 28 56 41 20 4d 65 |Davis SS|..(VA Me|
|00005ed0| 64 20 43 74 72 2c 20 53 | 65 70 75 6c 76 65 64 61 |d Ctr, S|epulveda|
|00005ee0| 2c 20 43 61 6c 69 66 3b | 20 55 6e 69 76 20 6f 66 |, Calif;| Univ of|
|00005ef0| 20 43 61 6c 69 66 6f 72 | 6e 69 61 20 61 74 20 4c | Califor|nia at L|
|00005f00| 6f 73 20 41 6e 67 65 6c | 65 73 3b 20 41 6c 7a 61 |os Angel|es; Alza|
|00005f10| 20 43 6f 72 70 2c 0d 0a | 50 61 6c 6f 20 41 6c 74 | Corp,..|Palo Alt|
|00005f20| 6f 2c 20 43 61 6c 69 66 | 29 0d 0a 41 6d 20 4a 20 |o, Calif|)..Am J |
|00005f30| 4d 65 64 20 38 33 3a 34 | 37 31 2d 34 37 38 2c 20 |Med 83:4|71-478, |
|00005f40| 53 65 70 74 65 6d 62 65 | 72 20 31 39 38 37 0d 0a |Septembe|r 1987..|
|00005f50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005f60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005f70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005f80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005f90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fa0| 0d 0a 0d 0a 41 62 73 74 | 72 61 63 74 0d 0a 0d 0a |....Abst|ract....|
|00005fb0| 20 20 20 20 20 41 20 73 | 65 6c 66 2d 61 64 68 65 | A s|elf-adhe|
|00005fc0| 72 65 6e 74 20 74 72 61 | 6e 73 73 63 72 6f 74 61 |rent tra|nsscrota|
|00005fd0| 6c 20 74 65 73 74 6f 73 | 74 65 72 6f 6e 65 20 73 |l testos|terone s|
|00005fe0| 79 73 74 65 6d 20 28 54 | 54 53 29 20 74 6f 20 70 |ystem (T|TS) to p|
|00005ff0| 72 6f 76 69 64 65 0d 0a | 70 72 6f 67 72 61 6d 6d |rovide..|programm|
|00006000| 65 64 20 74 65 73 74 6f | 73 74 65 72 6f 6e 65 20 |ed testo|sterone |
|00006010| 64 65 6c 69 76 65 72 79 | 20 74 68 72 6f 75 67 68 |delivery| through|
|00006020| 20 74 68 65 20 75 6e 69 | 71 75 65 6c 79 20 70 65 | the uni|quely pe|
|00006030| 72 6d 65 61 62 6c 65 20 | 73 63 72 6f 74 61 6c 20 |rmeable |scrotal |
|00006040| 73 6b 69 6e 20 77 61 73 | 0d 0a 64 65 76 65 6c 6f |skin was|..develo|
|00006050| 70 65 64 20 62 65 63 61 | 75 73 65 20 6f 66 20 74 |ped beca|use of t|
|00006060| 68 65 20 6e 65 65 64 20 | 66 6f 72 20 61 20 62 65 |he need |for a be|
|00006070| 74 74 65 72 20 6d 65 74 | 68 6f 64 20 6f 66 20 74 |tter met|hod of t|
|00006080| 65 73 74 6f 73 74 65 72 | 6f 6e 65 20 61 64 6d 69 |estoster|one admi|
|00006090| 6e 69 73 74 72 61 74 69 | 6f 6e 0d 0a 74 6f 20 68 |nistrati|on..to h|
|000060a0| 79 70 6f 67 6f 6e 61 64 | 61 6c 20 6d 65 6e 2e 20 |ypogonad|al men. |
|000060b0| 20 42 65 66 6f 72 65 20 | 74 68 65 20 74 72 69 61 | Before |the tria|
|000060c0| 6c 2c 20 74 68 65 20 33 | 20 70 61 74 69 65 6e 74 |l, the 3| patient|
|000060d0| 73 20 72 65 63 65 69 76 | 65 64 20 61 6e 20 69 6e |s receiv|ed an in|
|000060e0| 6a 65 63 74 69 6f 6e 20 | 6f 66 0d 0a 32 30 30 20 |jection |of..200 |
|000060f0| 6d 67 20 6f 66 20 74 65 | 73 74 6f 73 74 65 72 6f |mg of te|stostero|
|00006100| 6e 65 20 65 6e 61 6e 74 | 68 61 74 65 2c 20 61 6e |ne enant|hate, an|
|00006110| 64 20 73 65 72 75 6d 20 | 63 6f 6e 63 65 6e 74 72 |d serum |concentr|
|00006120| 61 74 69 6f 6e 73 20 6f | 66 20 65 61 63 68 20 72 |ations o|f each r|
|00006130| 65 70 72 6f 64 75 63 74 | 69 76 65 0d 0a 68 6f 72 |eproduct|ive..hor|
|00006140| 6d 6f 6e 65 20 77 65 72 | 65 20 6d 65 61 73 75 72 |mone wer|e measur|
|00006150| 65 64 20 61 74 20 30 2c | 20 34 2c 20 38 2c 20 32 |ed at 0,| 4, 8, 2|
|00006160| 34 2c 20 61 6e 64 20 34 | 38 20 68 6f 75 72 73 20 |4, and 4|8 hours |
|00006170| 61 6e 64 20 74 68 65 6e | 20 77 65 65 6b 6c 79 20 |and then| weekly |
|00006180| 66 6f 72 20 34 20 77 65 | 65 6b 73 2e 0d 0a 46 69 |for 4 we|eks...Fi|
|00006190| 76 65 20 77 65 65 6b 73 | 20 61 66 74 65 72 20 74 |ve weeks| after t|
|000061a0| 68 65 20 69 6e 6a 65 63 | 74 69 6f 6e 2c 20 74 68 |he injec|tion, th|
|000061b0| 65 20 54 54 53 20 74 72 | 69 61 6c 20 77 61 73 20 |e TTS tr|ial was |
|000061c0| 62 65 67 75 6e 2c 20 77 | 69 74 68 20 65 61 63 68 |begun, w|ith each|
|000061d0| 20 70 61 74 69 65 6e 74 | 0d 0a 75 6e 64 65 72 67 | patient|..underg|
|000061e0| 6f 69 6e 67 20 35 20 74 | 72 69 61 6c 73 20 63 6f |oing 5 t|rials co|
|000061f0| 6e 73 69 73 74 69 6e 67 | 20 6f 66 20 34 20 64 61 |nsisting| of 4 da|
|00006200| 69 6c 79 20 32 33 2d 68 | 6f 75 72 20 61 70 70 6c |ily 23-h|our appl|
|00006210| 69 63 61 74 69 6f 6e 73 | 20 66 6f 6c 6c 6f 77 65 |ications| followe|
|00006220| 64 20 62 79 20 33 0d 0a | 64 61 79 73 20 6f 66 20 |d by 3..|days of |
|00006230| 72 65 73 74 2e 20 20 49 | 6e 20 72 61 6e 64 6f 6d |rest. I|n random|
|00006240| 69 7a 65 64 20 6f 72 64 | 65 72 2c 20 65 61 63 68 |ized ord|er, each|
|00006250| 20 70 61 74 69 65 6e 74 | 20 72 65 63 65 69 76 65 | patient| receive|
|00006260| 64 20 54 54 53 73 20 6f | 66 20 76 61 72 79 69 6e |d TTSs o|f varyin|
|00006270| 67 0d 0a 74 65 73 74 6f | 73 74 65 72 6f 6e 65 20 |g..testo|sterone |
|00006280| 63 6f 6e 74 65 6e 74 2c | 20 31 20 6f 66 20 77 68 |content,| 1 of wh|
|00006290| 69 63 68 20 77 61 73 20 | 70 6c 61 63 65 64 20 6f |ich was |placed o|
|000062a0| 6e 20 74 68 65 20 69 6e | 6e 65 72 20 61 73 70 65 |n the in|ner aspe|
|000062b0| 63 74 20 6f 66 20 74 68 | 65 20 74 68 69 67 68 2e |ct of th|e thigh.|
|000062c0| 0d 0a 20 20 20 20 20 41 | 66 74 65 72 20 65 61 63 |.. A|fter eac|
|000062d0| 68 20 6f 66 20 74 68 65 | 20 34 20 64 69 66 66 65 |h of the| 4 diffe|
|000062e0| 72 65 6e 74 20 73 63 72 | 6f 74 61 6c 20 61 70 70 |rent scr|otal app|
|000062f0| 6c 69 63 61 74 69 6f 6e | 73 2c 20 62 75 74 20 6e |lication|s, but n|
|00006300| 6f 74 20 74 68 65 20 74 | 68 69 67 68 0d 0a 61 70 |ot the t|high..ap|
|00006310| 70 6c 69 63 61 74 69 6f | 6e 2c 20 74 65 73 74 6f |plicatio|n, testo|
|00006320| 73 74 65 72 6f 6e 65 20 | 61 6e 64 20 62 69 6f 61 |sterone |and bioa|
|00006330| 76 61 69 6c 61 62 6c 65 | 20 74 65 73 74 6f 73 74 |vailable| testost|
|00006340| 65 72 6f 6e 65 20 6c 65 | 76 65 6c 73 20 69 6e 63 |erone le|vels inc|
|00006350| 72 65 61 73 65 64 0d 0a | 73 69 67 6e 69 66 69 63 |reased..|signific|
|00006360| 61 6e 74 6c 79 20 62 79 | 20 32 20 68 6f 75 72 73 |antly by| 2 hours|
|00006370| 2e 20 20 41 74 20 34 20 | 68 6f 75 72 73 2c 20 74 |. At 4 |hours, t|
|00006380| 68 65 20 64 69 68 79 64 | 72 6f 74 65 73 74 6f 73 |he dihyd|rotestos|
|00006390| 74 65 72 6f 6e 65 20 76 | 61 6c 75 65 20 77 61 73 |terone v|alue was|
|000063a0| 0d 0a 73 69 67 6e 69 66 | 69 63 61 6e 74 6c 79 20 |..signif|icantly |
|000063b0| 65 6c 65 76 61 74 65 64 | 20 74 6f 20 77 69 74 68 |elevated| to with|
|000063c0| 69 6e 20 74 68 65 20 6e | 6f 72 6d 61 6c 20 72 61 |in the n|ormal ra|
|000063d0| 6e 67 65 2e 20 20 41 6c | 74 68 6f 75 67 68 20 69 |nge. Al|though i|
|000063e0| 6e 74 65 67 72 61 74 65 | 64 20 6d 65 61 6e 0d 0a |ntegrate|d mean..|
|000063f0| 68 6f 72 6d 6f 6e 65 20 | 6c 65 76 65 6c 73 20 64 |hormone |levels d|
+--------+-------------------------+-------------------------+--------+--------+
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